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Studies in cell culture have demonstrated that specific peptide sequences can upregulate procollagen synthesis in dermal fibroblasts, while others influence the activity of matrix metalloproteinases (MMPs) the enzymes responsible for collagen degradation and ECM remodelling

A 2014 review in Ecancermedicalscience documented that mebendazole-associated hepatotoxicity has been reported primarily at doses exceeding standard antiparasitic levels and with prolonged treatment duration

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In clinical trials, prophylactic use of carvedilol in cancer patients receiving anthracycline therapy has shown protective effects on left ventricular systolic function [158]

Western blot analysis RIPA Lysis Buffer (TransGen, Beijing, China) was used to extract total protein from tissues/fibroblasts and a Nuclear and Cytoplasmic Protein Extraction Kit (TransGen) was used to extract the protein from nucleus and cytoplasm of fibroblasts