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Addressing these gaps requires focused safety studies that prospectively track headache characteristics and control for baseline headache frequency, medication use and cosupplementation

Connolly HM, Crary JL, McGoon MD, Hensrud DD, Edwards BS, Edwards WD et al (1997) Valvular heart disease associated with fenfluramine-phentermine

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Int J Obes 47:939947 Suez J, Cohen Y, Valds-Mas R, Mor U, Dori-Bachash M, Federici S, Zmora N, Leshem A, Heinemann M, Linevsky R et al (2022) Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance

And Ill be very, very, very, very, very (did I say very enough?) clear: this is not prescriptive