The SELECT trial and subsequent renal subgroup analyses suggested that, in populations with both obesity and pre-existing cardiovascular disease, semaglutide not only reduced the risk of cardiovascular events but also slowed the decline of the estimated glomerular filtration rate (eGFR) ( As indications have expanded from diabetes to obesity, GLP-1RAs have increasingly entered routine care for women of reproductive age, including those with PCOS, in whom obesity and insulin resistance are highly prevalent ( 1.4 Rationalizing fertility-centered review of GLP-1RAs in PCOS: bridging metabolic-reproductive divide 1.4.1 Clinical paradox: tension between metabolic optimization and reproductive urgency While GLP-1RAs have been established as a first-line intervention for managing metabolic comorbidities in PCOS, their potential teratogenic risks and the requirement for strict preconception washout periods present a formidable clinical dilemma for reproductive specialists
Greco EA, Pietschmann P, Migliaccio S
Karakula-Juchnowicz H, Rog J, Juchnowicz D, et al
Oxidative stress in the pathogenesis of diabetic neuropathy
Potassium replacement is necessary to correct electrolyte imbalances and prevent complications related to hypokalemia or hyperkalemia
AR structure and activity The AR gene is located on the X chromosome at the locus Xq11-Xq12 (Figure 1B) 16,17,18
