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From the discovery of the GLP-1 fragment GLP-1(7-37) to the development of more stable and long-acting GLP-1 analogs, these milestones represent significant breakthroughs in the medical field

The weight loss effects observed with these medications result from both delayed gastric emptying and direct effects on appetite centers in the hypothalamus, leading to reduced hunger and increased satiety

Contraindications include personal or family history of medullary thyroid carcinoma or MEN 2 syndrome, pancreatitis history, severe GI or kidney disease, pregnancy, and breastfeeding

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With microdosing, patients begin at the lowest effective amount of the medication and increase the dosage more slowly

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