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The problem of spectral resolution and the validity of static whole tissue metabolite measurements has been partially addressed by increasing field strength, using spectral editing techniques that further resolve a peak of interest and functional 1 H-MRS with some limited improvement

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For example, in the case of mitochondrial fusion, the overexpression of Fzo1A/B or MFN1/2 prevents excessive fragmentation of mitochondria

Other previous experiments have shown that subcutaneous administration of rotenone resulted in a highly selective dopaminergic damage in neurons and -synuclein aggregation, similar to the Lewy bodies of PD [63,65]