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7), and increased serum and ileum GLP-1 levels (Fig

Am J Manag Care 31(8):e228e34 Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G (2012) Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

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It was designed for short-term use, typically 12 weeks or less, because sustained stimulant exposure raises the risk of tolerance, dependency, and cardiovascular complications