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Coffee, particularly stronger or acidic varieties, may stimulate stomach acid and digestive activity at the same time, which can occasionally increase stomach irritation in sensitive individuals

In addition, participants were required to adhere to the study visit schedule and the prespecified prohibitions and restrictions (Study Protocol)

Why NSAIDs require food but Tylenol does not NSAIDs block enzymes that protect the stomach lining, which can lead to ulcers and bleeding

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