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For a comprehensive summary of these trial results and Phase 3 updates, see our retatrutide clinical trials 2026 update

In the Phase 2 clinical trial (NEJM, 2023), participants on 12 mg dose lost up to 24% body weight over 48 weeks the best result among all weight loss drugs

Rosenbaum M, Sy M, Pavlovich K, Leibel RL, Hirsch J

Spichak, S

Were building a new category at the intersection of biology and accessibility to reimagine how people take control of their metabolism, appetite and longevity with solutions that deliver real results and work with the bodynot against it. Evolv says its GLP-1 supplement is only the start and that its biomimetic platform is being developed for other applications, including hair health and restoration, another area that is on the rise

doi: 10.1210/en.2013-1750