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This free radical damage leads to premature skin ageing

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The European Society For Clinical Investigation (ESCI), Utrecht, Netherlands

As epigenetic modifiers, STLs can modulate the p53 signaling pathway, suppress oncogenic signaling pathways, reduce the activation of major hepatocarcinogenesis-related oncogenes, and inhibit the epithelial-mesenchymal transition [110,111,112]

However, tesofensine is a novel compound with potential in human studies and may be a promising alternative for these patients [38]