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retatrutide is a triple GLP-1/GIP/glucagon agonist

Both affect BDNF and have some immunomodulatory properties

To elucidate the role of GLP-1Rs in the LS in mediating the anorexigenic effects of liraglutide, we used CRISPR/Cas9 technology to specifically knock down GLP-1R expression in LS GLP-1R neurons

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