retatrutide phase 2 trial results Dosage & Titration: Complete Escalation Protocol (5-30 mg) Retatrutide Delivers Significant Hemoglobin A1C

Now, glucagon on its own would push blood sugar up, which sounds like a problem

Malhotra A, Grunstein RR, Fietze I, Weaver TE, Redline S, Azarbarzin A, et al

More importantly for muscle-focused applications, the proportion of lean mass loss to total weight loss was similar to or better than other obesity treatments, with Retatrutide demonstrating significant improvements in total body fat mass reduction compared to both placebo and dulaglutide (a single-receptor GLP-1 agonist)

Treat the following as community-derived hypotheses, not validated outcomes: Hypothesis 1 Plateau breaking past retatrutide monotherapy Community framing is that adding cagrilintide engages a receptor system retatrutide does not target, which could theoretically extend weight loss past a retatrutide-monotherapy plateau

We're here to support that change every step of the way

We dont know yet if it is better or worse, Jay says