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The direct access to CNS allows to overcome limitations linked to the degradation, bioavailability problems and also to possible systemic side effects onset that occur if peptides are present in blood vessels after intravenous administration

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And sometimes, yes, it means evaluating whether the compounded formulation is performing as expected and considering a pharmacy switch

However, some of these findings come from animal experiments, observational studies, or early-stage clinical trials

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J Hep 2: 2