However, the drugs gastrointestinal side effects, including nausea, vomiting, diarrhea, and gas, while often mild and transient, can pose challenges for some patients
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If these diets do impair MBF in healthy humans this would suggest there is a population group that is apparently healthy but at a high risk of developing insulin resistance and T2D
What becomes structurally important from a reimbursement standpoint is that once a non-inferiority objective is not met, HTA bodies shift the assessment lens toward incremental benefit versus the strongest available alternative
N Engl J Med 2019;381:63746
Maskey AR, Kopulos D, Kwan M, Reyes N, Figueroa C, Mo X, et al