Conducted comprehensive characterization (particle size, PDI, zeta potential, loading efficiency, leakage and stability profiles)
Complete biotransformation and protection from oxidative stress are important to maintaining cellular integrityand tissue health.*
Normally produced in the lizard salivary gland, exendin can bind mammalian GLP-1R and bolster its activity
Also, only two GLP-1RAs (e.g., exenatide, dulaglutide) have been evaluated henceforth in NUD and the extent to which the efficacy of GLP-1RAs as a class effect is unknown
Generally, maintaining at least 72 hours between doses is the minimum safe interval for weekly injections, though aiming for as close to seven days as possible remains ideal
Treatment with prebiotics or with newly identified beneficial bacterial strains are potential interventions that will be used in the near future, and it will be important to evaluate their efficacy