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Although polymorphisms in genes such as NLRP3 and IL1B have not yet been comprehensively investigated, their central roles in mediating the inflammatory response to MSU crystals imply that genetic variations in these pathways may modulate the threshold at which asymptomatic hyperuricemia progresses to clinically significant tophus formation, by regulating the magnitude and duration of inflammatory responses

Most respondents were of European ancestry (78.3%), although the study also included substantial representation from Latino (12.9%) and African American (4.2%) ancestries

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