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When combined with spermine (SPM), it reduces the need for desalting and, compared with other matrix and dopant combinations, the MSA/SPM matrix provides mass spectra with higher resolution, fewer fragments, and a reduced intensity of alkali ion adduct peaks

M.FortainJ.et al (2023)

It can also increase risk of swelling or internal damage

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doi:10.1080/14992027.2021.1983215