Intrinsic Factor Inhibiting Conditions Conditions such as autoimmune disease or pernicious anemia cause an inability to make the intrinsic factor that is essential for Vitamin B-12 absorption
Beyond Neurotrophic Functions: HGF-MET Play a Role in Synaptogenesis and Neuroplasticity Circumstantial evidence indicates that MET is implicated in the synapse formation
Lung Cancer In 2017, a study found that men taking B12 supplements appeared to have an increase in lung cancer risk
Furthermore, an anti-inflammatory probiotic Lactobacillus reuteri , administered over 8 weeks reduced CRP and stress-induced heart rate in Veterans with PTSD and mild traumatic brain injury compared to placebo (Brenner et al., 2020)
On the other hand, gastrointestinal disturbances are critical early indicators of severe thiamine deficiency causing pediatric Wernicke Encephalopathy (54)
Why This Matters These findings likely represent just the tip of the iceberg, reinforcing the need for proactive screening, nutrition support, and multidisciplinary care in patients receiving GLP-1 therapy