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Koo, J., Burrows, L

Researchers should design their protocols with these differences in mind and avoid making direct comparisons to clinical trial outcomes without appropriate caveats

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However, we have demonstrated that GLP-1Rs are constitutively expressed and that GLP-1Rs alter cellular localization according to feeding status

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340 Furthermore, the increased production of inflammatory mediators like TNF- and the activation of stress kinases such as JNK, PKR, and IKK could promote the inhibitory serine phosphorylation of IRS-1, downregulate insulin signaling in the brain, and induce AD neurological dysfunction