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Some studies have shown reductions in systemic inflammatory markers such as C-reactive protein (CRP) in patients taking GLP-1 medications, though whether this translates to clinically meaningful joint pain reduction independent of weight loss is not definitively established
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Furthermore, GLP-1 and glucose-dependent insulinotropic polypeptides have been shown to induce substance P release from sensory nerves expressing TRPV1 and TRPA1, broadening the potential pain modulation mechanisms of GLP-1 and suggesting their application in peripheral pain management 64
Du, et al., 'The Effect of Retatrutide on Kidney Parameters in Participants With Type 2 Diabetes Mellitus and/or Obesity', Kidney Int
For Patients If you're considering or already using a GLP-1 medication, here's what I want you to know: You are not broken