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doi: 10.1016/j.molmet.2023.101805 17 WangYDilidaxiDWuYSailikeJSunXNabiXH

Clinical data shows MK-677 increases growth hormone levels by 89% and IGF-1 by 72% within four weeks, while maintaining these elevations throughout treatment

Unlike injectable drugs that have dominated the market so far, oral treatments do not require refrigerated storage (cold chain) and offer higher patient adherence

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The primary end point was PFS, while the secondary end points were OS, response rate, and safety.[22][Level of evidence B1] The median PFS was 18.3 months in the lenvatinib group and 3.6 months in the placebo group (HR progression or death , 0.21