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A number of genetic polymorphisms have been identified

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Clarkson CW, Xu YQ,Chang C,Follmer CH (1996): Analysis of the ionic basis for cocaine's biphasic effect on action potential duration in guinea-pig ventricular myocytes

Int J Biochem Cell Biol (2008) 40(10):19849.10.1016/j.biocel.2007.07.008 9 WatersMJBrooksAJ

For many exercise is arduous and unpleasant, and it has to be stacked on top of other demands, like working a job (or jobs), raising a family, and managing the relentless addictions and distractions of late capitalism