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Porphyromonas gingivalis and its LPS can translocate from the oral cavity to the gut, causing gut dysbiosis 111 , which is linked to increased hepatic expression of TLR2, TNF-, and IL-17, thereby promoting liver inflammation 112

FIGURE 1 3 GI tract, gut microbiota, and human metabolism The gastrointestinal (GI) tract, also known as the digestive system, is an essential organ system responsible for processing food and eliminating waste

doi: 10.1093/rheumatology/keq073 157 RygielKAMillerJGradyJPRochaMCTaylorRWTurnbullDM

However, for therapeutic effects, additional targeted supplements like thiamine or magnesium may be necessary during early recovery

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