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Then, in 2015, Lee and colleagues identified a previously overlooked open reading frame within the 12S ribosomal RNA gene of mtDNA and found that it encodes a functional peptide, MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) [1]

For example, melatonin at a physiological concentration of 1 nM reversibly modulates cell proliferation and increases levels of p53 and p21/WAF1, alters cell cycle, and decreases metastatic potential of breast cancer cells in the presence of serum or estradiol [25]

Glutathione peroxidase 3 (GPX3) suppresses the growth of melanoma cells through reactive oxygen species (ROS)-dependent stabilization of hypoxia-inducible factor 1- and 2-

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Mesenchymal stromal cells derived from various tissues: biological, clinical and cryopreservation aspects