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[DOI] [PubMed] [Google Scholar] 7.Stipanuk M.H., Coloso R.M., Garca R.A., Banks M.F

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This does not mean zero drug reaches CNS targets, but it does mean the fraction is likely small and the pharmacokinetic profile is poorly characterized for that route

Alterations of this current production of peroxides and free radicals damage structural components of the cell

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Thus, we are still far from a complete understanding of the biology of nociception and its applicability in clinical practice