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Future research must therefore pivot toward integrated, multi-targeted nutritional strategies that simultaneously address these interconnected pathways, moving beyond single-nutrient approaches to achieve personalized OA management (35)

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Abbreviations GLP-1 RA: Glucagon-like peptide-1 receptor agonist MACE: Major adverse cardiovascular events HR: Hazard ratio CI: Confidence interval HER: Electronic health record ICD: International statistical classification of diseases and related health statistical classification of diseases and related health problems CPT: Current procedural terminology BMI: Body mass index MRA: Mineralocorticoid receptor antagonist ACE inhibitor: Angiotensin converting enzyme inhibitor ARB: Angiotensin II receptor blocker SGLT2 inhibitor: Sodium-glucose co-transporter 2 GFR: Glomerular filtration rate HbA1c: Hemoglobin A1c STROBE: Strengthening the reporting of observational studies in epidemiology SD: Standard deviation PS: Propensity score SMD: Standardized mean difference References Nichols, G

Propylene glycol caprylate as a novel potential absorption enhancer for improving the intestinal absorption of insulin: efficacy, safety, and absorption-enhancing mechanisms

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