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[00:25:00] There's some interesting things about it
Durability of Results: Maintenance Studies: Tirzepatide (SURMOUNT-3): Continued treatment: Additional 5.5% weight loss Stopped treatment: Regained 14% of weight Conclusion: Need ongoing treatment Semaglutide (STEP-4): Continued treatment: Maintained loss, continued losing Stopped treatment: Regained most weight Conclusion: Need ongoing treatment Phentermine: FDA-approved for 12 weeks only Weight regain after stopping is universal Not a long-term solution All Weight Loss Medications: Obesity is chronic disease Medications treat symptoms, dont cure Stopping medication weight regain Long-term or indefinite use necessary for sustained results Safety Profile Comparison: Discontinuation Due to Side Effects: Tirzepatide: 6.2% Semaglutide: 6.9% Liraglutide: 9.9% Naltrexone-bupropion: 25% (very high) Orlistat: 15-20% Phentermine-topiramate: 8-10% GLP-1s have excellent tolerability considering their effectiveness
This lower-dose strategy can be particularly helpful for: As with all aspects of medical weight loss, microdosing is customized to your body, goals, and ongoing progress
The only legitimate way to access these medicines in the UK is through participation in a registered clinical trial, which can be found via NIHR Be Part of Research or ClinicalTrials.gov
The medication works by mimicking glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), two natural hormones that regulate hunger and blood sugar
Glucagon is a hormone produced in the pancreas that sends messages to the liver to release stored sugar and raise blood sugar levels
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