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Semaglutide-treated rats show downregulation of many type IV and type VI collagens and laminin genes that compose the basement membrane, as well as the type I, type III, and type V collagens and fibrillins that compose the interstitial matrix ( Figure 4B )

Conclusion GLP-1 therapy represents a significant advancement in weight management, offering both metabolic and appetite-regulating benefits

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With the loss of exclusivity, several companies, including Sandoz, Apotex, Teva, Taro, Vimy Pharma, Hims & Hers, and Biocon, have filed applications to launch generic versions of semaglutide, but they are pending Health Canadas regulatory approval

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