When prescribing AOMs in older adults, consideration of drug-drug interactions should be sought in light of polypharmacy [76], as well as side effects, either directly through the pharmacological properties of the AOM, or indirectly through rapid and maintained weight loss, that may be amplified in older adults
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Besides, vitamin B12, methylcobalamin has neurological effect indirectly, methylation of myelin shelth phospholipids via 5-methyltetrahydroxyfolate-homocystine methyltransferase (MTR) reaction
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Examples include: Historically autoimmune diseases have been treated with immune suppression