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For retatrutide specifically, sticking to the 28-day window is the safer choice

Weight loss outcomes vary by agent and dose: high-dose semaglutide (2.4mg/Wegovy) has shown mean weight reductions of approximately 15% in the STEP clinical trials, while liraglutide (3mg/Saxenda) typically achieves 5-8% weight loss

For the full analysis inclusive of demographics, comorbidities, and social drivers of health data for the population, methodology, findings (including dispensing trends, which indicates whether the patient picked up the medication and can be a proxy for understanding medication adherence), limitations, and citations you can view the complete report on MedRxiv

For once-weekly injections, administer the missed dose as soon as possible if within the specified timeframe (e.g., within 5 days for semaglutide, at least 3 days before the next dose for dulaglutide)

Any telehealth or direct-access pathway should include screening questions

This ensures that patients receive the most benefits while maintaining safety