If that side-effect pattern sounds familiar, our article on managing nausea on GLP-1 can help you think through day-to-day symptom support
Common side effects include nausea, vomiting, diarrhoea, and constipation consistent with the known GLP-1 receptor agonist class profile
Clinical trials show that Semaglutide is a promising option for treating PCOS, as it helps with weight loss, improves insulin sensitivity, and normalizes menstrual cycles
Preclinical studies (in vitro) show that Semaglutide has anti-tumour properties across a few cancer types: inhibiting proliferation, inducing apoptosis, and suppressing metastasis, but this data is quite conflicting and usually takes into account only the effect of Semaglutide on the GLP-1 receptor and not the effect of adiposity and other endocrine systems
GIP receptor activation plays a different but equally important role by: Improving insulin sensitivity at the cellular level , allowing cells to respond more effectively to insulin Enhancing fat metabolism and reducing signals that promote fat storage Reducing post-meal glucose spikes by improving glucose disposal This second pathway directly addresses one of the core drivers of insulin resistance: poor cellular response to insulin despite high circulating levels
George J, Struthers AD
