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While working with the Steelers in the early 1990s, the lack of an objective, reliable instrument to evaluate concussion symptoms became very apparent to Dr

32 Introduction of Lys at position 9 showed a significant loss of binding and potency (830- and 160-fold, respectively) when the resulting peptide was tested on RIN T3 cells

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Reduced MTHFR activity reduced methionine regeneration reduced SAM production reduced methylation capacity across all SAM-dependent methyltransferase reactions consequences that propagate through epigenetics, neurotransmitter metabolism, creatine synthesis, phosphatidylcholine production, and the broader biochemistry that SAM sustains