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Consequently, this increases the oxidation of methionine to a sulfoxide, with the consequences we have already mentioned

But with a 2mg/mL concentration (5mL of water added), that same 4mg dose requires 2.0mL of liquid, which is an entire insulin syringe worth and creates a large, uncomfortable injection volume

So if your main barrier is appetite dysregulation, food noise, or post-meal cravings, AOD-9604 is not a like-for-like substitute for semaglutide or tirzepatide

doi: 10.3389/fphar.2025.1513125 Received 17 October 2024 Accepted 07 March 2025 Published 28 March 2025 Volume 16 - 2025 Edited by Eliot Ohlstein, Drexel University School of Medicine, United States Reviewed by Robertas Badaras, Vilnius University, Lithuania Qiyan Wang, University of Michigan, United States Updates Copyright 2025 Di Fulvio, Rathod and Khader

We tested this idea using genetic and pharmacological inhibition of TS activity