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Research to this point is somewhat inconclusive

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Bedtime Kratom Use Patterns and Associations with Sex and Chronic Pain Status Across all beginning-of-day entries over the 15-day EMA period, participants reported bedtime kratom use on 23.4% of days, no bedtime use on 74.7% of days, and unsure on 2.0% of days

One of the key mechanisms underlying the dark and shrunken morphology of granule cells in the DG during epileptic episodes is excitotoxicity, primarily mediated by excessive glutamate release (Wang and Qin, 2010)