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Semaglutide and tirzepatide have not been studied prospectively in nursing parents, leaving a critical evidence gap

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Tirzepatide demonstrated superior efficacy compared to placebo and other common glucose-lowering therapies, including semaglutide 1 mg, dulaglutide, insulin degludec, and glargine

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Intramuscular administration allows B12 to bypass hepatic metabolism and enter systemic circulation directly, which is why this route differs from oral supplementation