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A normally functioning Wnt signalling pathway ensures tissue regeneration and maintenance of tissue integrity, while deregulated Wnt plays a role in aging and cancer [ 12 ]

As an important mode of intercellular communication, EVs play a critical role in the pathogenesis of NAFLD and its actions in NAFLD were reviewed recently [103]

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The progress of depression plays a crucial role in abnormalities in glutamate, e.g., chronic or remittedrecurrent MDD subjects showed further reduction in glutamate level in PFC as compared with the first episode depressed subjects (119)

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