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It activates two of the same three receptors (GLP-1 and GIP), missing only the glucagon pathway

Indeed, early retrospective cohort studies and post-hoc analyses suggested that GLP-1RAs might delay DR progression or improve outcomes, with one study reporting that 80% of patients on continuous therapy achieved either improvement or stabilization of their DR status [78, 79]

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Often, dose reduction and side-effect management can work well

Semaglutide is associated with increased neoplasm and tumorigenesis, specifically in the thyroid, bladder, colorectal, and pancreas

Our data indicate that GLP-1RA/tesaglitazar might hold therapeutic value for conditions characterized by hyperglycaemia and insulin resistance