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Sensitivity analysis to mitigate bias concerning ethnic and geographical origin To assess whether cross-study population background would influence our external-control comparisons, we performed a sensitivity analysis using three independent PBMC single-cell RNA sequencing datasets generated from China/Asia-based cohorts (GSE279452 60 , GSE206295 61 , and GSE168732 62 )

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Very-long-chain fatty acids (VLCFA: 17-26 carbons long) are preferentially oxidized in the peroxisomes