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Early initiation of metformin treatment plus an SGLT-2 inhibitor is recommended in most people with type 2 diabetes, followed by the addition of glucose-lowering agents as needed to achieve individualised glycaemic targets (Table 2)

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Circulating Fe 3+ enters cells with the assistance of transferrin and subsequently converts to Fe 2+ ( 2+ can catalyze the generation of metabolically toxic reactive oxygen species and phospholipid peroxide through the Fenton reaction, leading to cell damage or death (Figure 4)

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