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PLoS ONE 8 , e60324 (2013)

An elegant solution allowing a dynamic adjustment of plasticity rules in a neuron is a sliding threshold for LTP and LTD as proposed in the Bienenstock-Cooper-Munro model (Bienenstock et al., 2004)

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Conversely, animal models have also established that low levels of histamine-induced depression-like behavior, decreased locomotor activity in the home cage, and impaired aversive memory, leading to a decrease in wakefulness as well [185]

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The difference between 8mg (22.8%) and 12mg (24.2%) is only 1.4 percentage points