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Chronic hypoxia promotes ceramide hydrolytic metabolism by activating the HIF-2/Acer2 signaling pathway, and thereby downregulates PP2A activity The above study found that hypoxia caused -syn hyperphosphorylation by inhibiting PP2A activity

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as lycopene harbors the most potent antioxidative effects among carotenoids, its chemopreventive effects on the premalignant lesions is noted

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