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In the STEP 1 trial, once-weekly semaglutide 2.4 mg produced an average weight reduction of 14.9% compared with 2.4% with placebo over 68 weeks

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however, specific details of drug levels achieved in different tissues were not provided

The complex process leading to the production of these multiple species of GLP-1 affords multiple levels of control over what is ultimately secreted by the cell

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