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These hypotheses remain research questions, not final conclusions

However, future retatrutide trials of longer duration and greater sample sizes may show even greater weight loss effectiveness compared to tirzepatide

The first common stall window hits around months 3 to 5

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Pulsatile GH signals also activate organ-specic second messenger signaling pathways, such as the Signal Transducer and Activator of Transcription 5B (stat5B) in the liver, with subsequent induction of specic genomic responses in relevant target tissues

Based on these results, tirzeaptide 5mg seems to perform similarly to semaglutide 2.4mg, whereas tirzepatide 10mg and 15mg doses seem to produce greater weight loss than semaglutide 2.4mg (Figure 3)