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CrossRef Apple polyphenol extract mitigates high-fat diet induced cognitive impairment in C57BL/6 mice via a sex-dependent mechanism Jieyu Ma, Jiaxin Li, Le Wang, Jinlin Ma, Shilin Chen, Wenxue Luan, Xintong Tian, Siyuan Shang, Xinli Li Food Bioscience .2026

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M., Unger, J., Karsbl, J

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Another trial, this one of exenatide, showed no significant changes in amyloid or tau in participants cerebrospinal fluid (the clear liquid around the brain) but it did find a reduction in amyloidbeta in extracellular vesiclespackages cells release to communicate with each otherwhich could be an early biomarker of Alzheimers disease, per the researchers

Ezekowitz, M