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Start Your Evaluation Safety Comparison: Side Effects and Contraindications Both medications have significant side effect profiles, but the nature of those side effects differs dramatically: Semaglutide side effects are primarily gastrointestinal: nausea (44%), diarrhea (30%), constipation (24%), and vomiting (24%)

Incorporate prebiotic fibres like lentils and beans to support digestion Adding prebiotic fibres such as lentils and beans can help support healthy digestion during a compounded semaglutide plan

PBH can be profoundly disabling, manifesting symptoms ranging from fatigue and headaches to severe neuroglycopenia, leading to loss of consciousness and/or seizures, sometimes necessitating hospitalization [4, 5]

Fever or active illness

For patients who experience severe "histamine dumps" at night, which can cause insomnia, sudden tachycardia, or night sweats, taking the dose in the late afternoon or early evening may provide targeted mast cell stabilization during the most vulnerable hours

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