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Glucagon- and GCGR-positive cells were manually counted in five mouse islets using Fiji (version 1.53t, National Institutes of Health, MD, USA, No immunoreactivity in pancreatic islets was observed with the ab75240 antibody in Gcgr / mice [20]

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105 These results were supported by Srinivasan et al., 106 showing in their study an improvement in weight and insulin sensitivity, where using GLP-1RAs in monotherapy versus metformin achieved more than 5% weight loss