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It is possible that the optimal synergistic dosages of these vitamins have not yet been identified or that compounds produced during the metabolism of homocysteine may increase inflammation and override the beneficial effects of supplementation.26 Diabetes Elevated plasma homocysteine has been associated with an increased risk of insulin resistance and type 2 diabetes

Studies have also shown that long-term oral administration of baclofen can improve ASD-like behaviors in VPA-exposed mice after weaning, and prenatal intervention in offspring can also improve ASD-like behaviors, demonstrating the potential of early intervention with GABAB receptor agonists in treating ASD (143)

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