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While large-scale clinical trials are still limited, the existing data is encouraging

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In cases of complete LOF mutations in MC4R , the receptor becomes nonfunctional, rendering agonists ineffective

There may sometimes be small pigmented tints to an otherwise pink or granulomatous mass [31]

This selection also ensured sufficiently large sample sizes for robust disease-disease association analyses, while minimizing biases from platform heterogeneity

Marzioni M, et al