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EQ-5D-5L Health State Index (UK) score improvements with tirzepatide 10 or 15 mg were not significantly different to those with placebo (LSM (SE) change from baseline to week 72- tirzepatide 10 mg ( n = 281): 0.03 (0.01)

Due to the compounds plasma half-life of approximately 3.86.9 hours [5] , twice-daily (BID) dosing may provide more sustained NNMT inhibition

If nausea is the main issue, practical steps may help

& Mancini, G.J

"Screening for inter-individual splicing differences in human GSTM4 and the discovery of a single nucleotide substitution related to the tandem skipping of two exons"

Wegovy is approved for weight loss in some teens over 12, but mental health support is extra important in younger patients