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GIPR antagonism and GLP-1R agonism both modulate DVC gene programmes implicated in synaptic plasticity We next performed cell-type prioritization analysis using Augur 42 to determine which types of neurons were most affected by individual drug treatment in the DVC (Fig

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The EMPEROR-Preserved trial demonstrated a significant 29% reduction in HF-related hospitalizations with empagliflozin, highlighting the efficacy of SGLT2 inhibitors in improving clinical outcomes in HFpEF patients, regardless of diabetes status [5]