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119 Conversely, at the N-terminal domain, a non-catalytic regulatory haem sensor negatively impacts the enzymatic activity of CBS upon reduction and completely inactivates the enzyme upon binding of nitric oxide or carbon monoxide

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105,393,394,395 Conclusions In summary, toxic encephalopathies are primary astrocytopathies, in which toxic substances are accumulated by and damage astrocytes, with neuronal loss being secondary to astroglial homoeostatic failure

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[41] Almeida, E.B., Santos, J.M.B., Paixo, V., Amaral, J.B., Foster, R., Sperandio, A